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Nasal sprays formulated outside the isotonic range (270330 mOsm/kg) can cause irritation and impair the nasal mucociliary clearance apparatus the cilia-driven transport system that moves mucus, particles, and pathogens from the nasal cavity toward the nasopharynx

3 The UK National Institute for Health and Care Excellence (NICE) states that a cut-off of 200 ng/l identifies 97% of people with B12 deficiency, and a level below 100 ng/l is usually accompanied by metabolic or clinical evidence of B12 deficiency