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They also play crucial roles in the cardiovascular system, nervous system, skeletal growth, and reproductive function, underscoring the systemic effects of hormonal imbalance [42]

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Lippincott, Williams and Wilkins, 178-187, 2003

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MD simulations further elucidate the dynamic behavior of enzyme-inhibitor complexes under physiological conditions, revealing the roles and interactions of key amino acid residues during the binding process 47

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