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Inhibition of PHGDH reduces the production of -ketoglutarate (-KG), serine and NADPH, and induces cell death by elevating ROS levels (131)

Possessing a BTB domain at the N-terminal region, Keap1 serves as an adaptor for the Cullin 3-based ubiquitin E3 ligase for Nrf2 (Zhang et al., 2004

Curcumin administration and the effects on psychological status and markers of inflammation and oxidative damage in patients with type 2 diabetes and coronary heart disease

Los estudios realizados en modelos de roedores indican una mayor angiognesis relacionada con la regulacin al alza del VEGFR2 y la activacin de la va de sealizacin Akt-eNOS en las clulas endoteliales vasculares