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P-T (placebo to tesamorelin) refers to the group of patients who received placebo for Weeks 0-26 and were switched to tesamorelin (treated open label) for Weeks 26-52
The stack works by leveraging the unique roles of the three peptides: BPC 157: Tissue Stabilization and Angiogenesis BPC 157 provides a foundation for repair by stabilizing local tissue and promoting the formation of new blood vessels (angiogenesis)
It also induces the reverse transport of these transporters ( 2.1.2 Vesicular monoamine transporter 2 inhibition METH inhibits vesicular monoamine transporter 2 and disrupts monoamine storage in synaptic vesicles ( 2.1.3 Calcium dysregulation and excitatory neurotransmission METH enhances glutamate release, leading to NMDAR overactivation and increased calcium influx into neurons ( 2.1.4 BBB disruption METH compromises BBB integrity, allowing peripheral immune cells to infiltrate the CNS ( 2.2 Neurotoxic mechanisms METH induces neurotoxicity via a combination of oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation
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