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Therapeutic focus: Cagrilintide is being studied specifically for weight management, appetite suppression, and improved glycemic control, both alone and in combination with GLP-1 receptor agonists like semaglutide

Prescription weight-management medications may be used (in combination with a reduced-calorie diet and increased physical activity) for people with one of the following conditions: A body mass index (BMI) of 30 or higher A BMI of 27 or higher with a weight-related condition such as high blood pressure or type 2 diabetes GLP-1 and weight-management medications may also be prescribed for reasons outside of this list

At mouse embryonic day (E) 8.0, a proportion of cells in ventral foregut proximal to mesodermal cells adopt a hepatoblast (HB) fate, being bipotent for hepatocytes and cholangiocytes (Lotto et al., 2023)

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