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Because it avoids hepatic first-pass metabolism, circulating citrulline is primarily cleared by the proximal renal tubule, where it is enzymatically converted to arginine

Joseph Pizzorno, ND, Editor in Chief, highlights this key advantage: My opinion is that unmodified oral glutathione is unlikely to consistently elevate cellular levels. Studies confirm that IV glutathione effectively raises systemic levels, particularly in key detoxification organs like the liver and kidneys

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