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A practical framework is to separate baseline, follow-up, and symptom-triggered testing

Doctors ran countless tests but found nothing conclusive

Doctors often incorporate periodic reviews to decide if the dosage should be maintained, increased, or reduced

This mutation in mice nicely recapitulates the human vascular EDS phenotype, including thin and fragile skin, aortic aneurysm and rupture, and abnormal collagen fibrillogenesis in skin, aorta, and bowel