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The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction

This balancing act is critical because glucagon classically raises blood glucose (opposing insulin's effects), but when combined with GLP-1 agonism, the glucose-raising effects are counteracted while the metabolic benefits of increased energy expenditure and hepatic fat burning are preserved

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