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The mucosal layer is a key component of the intestinal barrier system, and emerging therapies for its protection focus on a three-step strategy of thickeningaugmentationquality enhancement: First, orally administered ROS-responsive thiolated hyaluronic acid hydrogel (HASH) has been shown to form an artificial mucous-like layer at the lesion site [409], physically blocking pathogen invasion and remodeling the microbiota

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The dual-targeting significantly increased the permeability of 3-PLG-dopa-A-GSH (P app : 14.61 10 6 cm/s) compared to the non-targeted 3-PLG-dopa (P app : 12.39 10 6 cm/s) group (Fig