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Testosterone replacement therapy is a medical treatment designed to restore testosterone levels in men with clinically low T, defined by the American Urological Association as total testosterone below 300 ng/dL on two separate morning blood draws

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In the BLOOM trial, patients treated with lorcaserin achieved highly significant and absolute weight loss in 1 year, and continuous treatment with lorcaserin over 2 years helped two-thirds of the patients maintain a weight loss of 5% or greater [83]