glp-1 discovery receptor assay: drug in the metabolic field Current Insights, Advantages and Challenges

35 , 487503.e487 (2023)

During the oxidative stress induced by high glucose levels in diabetes, gomisin A could promote osteoblast differentiation by modulating the expression of HO-1, antioxidant enzymes, and osteoblast differentiation molecules, as well as the maintenance of mitochondrial homeostasis

Nevertheless, it is increasingly evident that the antiinflammatory actions of GLP-1 and related mimetics represent key biological effects of agonizing the GLP-1 receptor, and these findings are considered to be of direct relevance to the renoprotective effects seen with GLP-1 mimetics

As one review notes for steroids, intratympanic delivery yields perilymph concentrations ~260 times higher than IV/oral doses (pills)