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Neuroimage 55 , 11591168 (2011)

A Comprehensive Review on the Pharmacokinetics and Drug-Drug Interactions of Approved GLP-1 Receptor Agonists and a Dual GLP-1/GIP Receptor Agonist

have shown that elevated levels of serum ammonia and myostatin contribute to sarcopenia in cirrhosis.21 And so a vicious circle is formed when a cirrhotic patient develops sarcopenia, given that there is a decrease in the elimination of ammonia in sarcopenic patients, which in turn, leads to a higher risk for developing hyperammonemia and HE.22 The detoxification of ammonia through the administration of L-ornithine L-aspartate (LOLA) in a murine model of sarcopenia and steatohepatitis significantly improved mean body mass, hand grip strength, and mean diameter of muscle fiber, in the group supplemented with LOLA vs

Iron chelators like deferoxamine (DFOM) reduce cellular iron levels and inhibit ferroptosis, as demonstrated by Yang et al