Emerging evidence suggests that GLP-1 medications themselves may influence gut microbiota composition, though more human studies are needed to fully understand these effects
Importantly, the BBB functions as the core of the neurovascular unit (NVU), whose integrity depends on the coordinated homeostasis of surrounding neurons, astrocytes, and the basal lamina
The sex ratio among all inpatients was approximately 50:50, whereas among all patients with ASCVD as well as those with ASCVD and obesity without diabetes mellitus only around 1/3 were women
The trial demonstrated that semaglutide significantly reduced the risk of a major kidney event, including kidney failure, a 50% or greater reduction in estimated glomerular filtration rate (eGFR), or death from kidney-related or cardiovascular causes, in patients with CKD and Type 2 diabetes