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This controlled release was demonstrated in a comparative study where niosomes maintained drug release for over 24 h, whereas conventional liposomes released their payload within 4 h upon enzymatic exposure [124]

As early as 1998, cytochrome P450 was introduced within HSV-I, enabling conversion processes whereby cyclophosphamide becomes activated specifically inside malignant tissues, leading toward notable anticancer effects evidenced across medulloblastoma atypical teratoid/rhabdomyosarcoma brain neoplasms among others (105, 106)