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[11] Additionally, Rich suggested avoiding choline or TMG supplementation, as it could push the BHMT pathway at the expense of the methionine pathway, and to avoid over-supplementing with different forms of folate that would compete for absorption

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4.4 Anti-inflammatory effects in neuroinflammation and neurodegenerative diseases Neuroinflammation is characterized by immune cells in the central nervous system (CNS), mainly microglia and astrocytes, remaining persistently activated, which is regarded as a predominant mechanism in numerous neurodegenerative and neurological diseases (244)