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Furthermore, even increases over 120% of muscle l-carnitine concentration were not able to modify long-chain fatty acid uptake, fat content, and carnitine palmitoyltransferase I and II (CPT I and II) activity in the skeletal muscle of control animals

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lean muscle mass loss may also be of greater clinical significance People with cardiovascular disease or arrhythmias : The observed increase in resting heart rate with GLP-1 and glucagon receptor agonism warrants careful monitoring in those with established heart disease or rhythm disorders People with pre-existing diabetic retinopathy : Rapid improvement in HbA1c may be associated with early worsening of retinopathy