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MOTS-c is usually dosed in the morning on training days, ideally 30-60 minutes before exercise - that lines up with the peptide's natural exercise-induced expression pattern and is supported by animal-study timing data

These findings suggest that GLP-1R signaling remains functional in Bbs5 / mice and could represent a promising therapeutic target for the hyperphagia and obesity associated with BBS

From a medical perspective, the main goal of treatment is to improve cardiometabolic control

When GLP- 1 receptor agonists are used to treat T2DM, there is also a noticeable reduction in post-meal glycemic fluctuations due to their short-term, transient effect on slowing gastric emptying