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Several studies have reported decreased expression of NMDA (73, 76, 77) and AMPA receptor subunits (77, 78) in PFC of depressed individuals

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The theoretical 3-8% additional weight loss from adding cagrilintide to tirzepatide doesn't justify the significantly amplified side effects, 2-3x higher cost ($1,200-2,400 monthly), lack of physician support for experimental protocols, and unknown long-term safety profile