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The results of LDSC analysis show weak evidence of a genetic correlation between SLE and ursodeoxycholate ( rg = 0.0395, se = 0.2454, p = 0.8722), taurodeoxycholate ( rg = 0.1601, se = 0.1715, p = 0.3503), N1-methyladenosine ( rg = 0.0427, se = 0.362, p = 0.7538), 1,5-anhydroglucitol (1,5-AG) ( rg = 0.0395, se = 0.0840, p = 0.6383), 1-arachidonoylglycerophosphocholine ( rg = 0.0320, se = 0.1026, p = 0.7554), isobutyrylcarnitine ( rg = 0.1165, se = 0.1219, p = 0.3392), palmitoleate (16:1n7) ( rg = 0.2461, se = 0.1551, p = 0.1124), and 1-oleoylglycerophosphoethanolamine ( rg = 0.1058, se = 0.2077, p = 0.6105), suggesting that the shared genetic component did not confound the MR estimates (Supplementary Table S1)

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