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Key Points Adrenocorticotropin (ACTH) has a key role in mediating the stress response by acting on a unique membrane receptor in the adrenal gland to stimulate glucocorticoid production Inactivating mutations in the ACTH receptor, or in an accessory protein essential for its expression on the cell surface, cause an inherited syndrome of ACTH insensitivityfamilial glucocorticoid deficiency Disturbances of ACTH-receptor expression or function are often found in benign and malignant adrenal neoplasms Altered responsiveness to ACTH is often present as a secondary phenomenon in several common disorders including depressive illness and septic shock This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 189,00 per year only 15,75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

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