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Under normal physiological conditions, the glycolytic activity of TECs remains low, and ATP generated through aerobic glycolysis accounts for only a minor proportion (4%) of total ATP production ( During AKI, mitochondrial FAO and the transport of FAs into mitochondria are significantly impaired due to mitochondrial dysfunction and disruption of quality control mechanisms ( During both early and late reperfusion phases following IR injury, there is a notable increase in glucose uptake and glycolytic activity in the renal cortex

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Indika N-LR, Frye RE, Rossignol DA, Owens SC, Senarathne UD, Grabrucker AM, Perera R, Engelen MP, Deutz NEP (2023) The rationale for vitamin, mineral, and cofactor treatment in the precision medical care of autism spectrum disorder

Potential approval lands in late 2027