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This peptide hormone is well known for its mediative effect in regulating cellular glucose transport in the periphery and has been demonstrated to cross the BBB through insulin transporters [128] to act on insulin receptors which are widespread throughout the brain, localized on neurons, astrocytes, and microglia [129,130,131]

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doi: 10.3389/fimmu.2021.745535 164 BouchaudGCastanLChesneJBrazaFAubertPNeunlistMet al

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