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However, hypersensitivity or allergic reactions to current medications, as well as defects in certain BBSome genes that disrupt NPY2 receptor trafficking to primary cilia, may limit the effectiveness of these therapies in specific BBS cases (47)

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Spacing the grapefruit and the medication by a few hours will not eliminate the interaction

Table 1 shows that high-altitude hypoxia induced a deviation in the TCA cycle and free fatty acids metabolism, especially for the pivotal molecules of 3-hydroxybutyrate, while L-carnitine combined with trimetazidine partially rectified the metabolic disturbance