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The proposed framework reconceptualises space as the critical interface linking material flows, governance systems, and everyday practices, embedding circularity within the socio-spatial fabric of urban environments (Williams, 2021)

The responsible agent is not known, but we have very recent evidence for presence of amyloid deposition and misfolded proteolipid protein in the brains of progressive MS patients supporting the proteopathic theory (Tsutsui et al., 2024)