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In a 68-week clinical trial, participants on Wegovy (semaglutide) lost an average of 14.9% body weight compared to 2.4% in the placebo group

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[1] It was engineered by Novo Nordisk from liraglutide's backbone through three key structural changes: (1) substitution of alanine with -aminoisobutyric acid (Aib) at position 8 to resist DPP-4 cleavage, (2) attachment of a C18 fatty diacid side chain at lysine-26 via a two-unit miniPEG spacer enabling high-affinity, reversible albumin binding, and (3) substitution of arginine-34 with lysine to allow site-specific acylation