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"Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 randomized clinical trial." JAMA , 331(1), 38-48

reduce to 1.7 mg if not tolerated Zepbound Start: 2.5 mg weekly for 4 weeks, then titrate to 5, 10, or 15 mg Intermediate titration doses (7.5, 12.5 mg) are sometimes not covered beyond 4 weeks Missed doses

This represents true muscle cell multiplication rather than just size increase

Why site rotation is non-negotiable Injecting into the same spot repeatedly causes lipohypertrophy, a condition where hardened lumps of fatty and fibrous tissue develop under the skin