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For instance, studies demonstrate distinct gene expression patterns and immune cell infiltrates between eutopic and ectopic tissues, and across lesion locations, suggesting variable responsiveness to immunomodulatory or microbiome-targeted therapies (27)

Hence, pharmaceuticals that target the NRF2 pathway can influence multiple pathways involved in the neurodegenerative process, and therefore hold potential to become therapies that can significantly modify the course of neurodegenerative diseases

Br J Clin Pharmacol 1980;10 Suppl 2:291S-8S