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Upon transfection or transduction with genes encoding for one or multiple drug metabolizing enzyme genes, HepG2 cells have been shown to be a valuable model system to study the role of bioactivating enzymes in the cytotoxicity of toxicants (Vignati et al., 2005

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(2018) in California, carried out a study on 2,310 people with MS and 4,819 controls, by questionnaires concerning lifestyle (diet, caffeine consumption, and cigarette smoking), and environmental and occupational exposures to pesticides or herbicides