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The analysis of 4887 participants treated with tirzepatide and 2,328 participants in the control groups identified 142 participants who developed at least one MACE-4p (inclusive of cardiovascular mortality, myocardial infarction, stroke, and hospitalization for unstable angina) and confirmed the cardiovascular safety with an hazard ratio (HR) of 0.80 (95% CI 0.571.11) for the comparison between tirzepatide and controls

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The drug led to an average weight loss of 70.3 pounds over 80 weeks in patients with obesity, with 45% of patients on 12 mg of the once-weekly injectable retatrutide losing up to 30% of their body weight, the drugmaker, Eli Lilly and Company, said in a news release

These changes at the genetic level lead to a decrease in hepatic triglyceride levels, improved insulin sensitivity, and a reduction in inflammatory and fibrotic pathways related to NF-B and transforming growth factor- (TGF-)