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After each increase, blood levels peak over 24 to 72 hours, when nausea and fullness are most likely to return. These effects usually ease during the four-week hold

[DOI] [PubMed] [Google Scholar] 60.Szabo S., Tache Y., Somogyi A

A: It is a synthetic peptide that mimics alpha-MSH signaling and activates MC1R on melanocytes, which can increase melanin production and lead to gradual skin darkening

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