no appetite on tirzepatide Suppression Timeline: What to Expect at Each Stage Appetite gone after first 2.5mg

10.1016/j.tips.2017.04.005 77 QinS.TangH.LiW.GongY.LiS.HuangJ.et al (2020)

Anyone tempted to notice that 2 mg is reassuringly close to the communitys 1.7 mg figure should notice instead that a rodent wound-chamber method is not a dose-finding study, and that the resemblance is a coincidence of scale rather than a validation

For most patients today, GLP-1 medications or dual agonists like tirzepatide represent proven, effective options with established safety profiles

However, GLP-1R internalization was previously found to be independent of -arrestin-1 14,34 , and a positive role for -arrestin-1 in stimulating insulin release has been reported 14