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Rather than relying on willpower alone, they support the biological processes that influence hunger and fullness

The no-calorie sweetener allulose possesses health benefits and induces GLP-1 release, activates vagal afferent signaling, reduces food intake/hyperglycemia, promotes glucose tolerance, and corrects arrhythmic overeating

One theoretical concern: aggressive caloric restriction accompanying drug-induced satiety reduction could suppress gonadotropins in women with low body fat reserves

The ATTAIN-2 results reinforce the potential for orforglipron, as a once-daily oral, to deliver meaningful weight loss and A1C reduction, consistent with similar landmark trials for injectable GLP-1s, Custer added