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Description

In addition to the cardiovascular protection afforded by glucose metabolism regulation, a large body of evidence from animal and cellular studies has corroborated the beneficial effects of GLP-1 RAs on conditions such as heart failure (HF), hypertension, and ischemic cardiomyopathy

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As such, they may overlook symptoms that individuals find bothersome but less dangerous, or that occur less frequently

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In a preliminary clinical trial, the results of exenatides non-metabolic effects in patients with schizophrenia were non-significant, which indicated challenges in translating the cognitive-enhancing effects observed in animal studies to humans (Ishy et al., 2017)

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Therefore, future studies may benefit from an evaluation of these antidiabetic drugs and their comparisons in dysmetabolic patients with hypogonadism to verify their efficacy and potential different impact on the HPG axis

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