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Products should also be pH-balanced to melanated skin (meaning on the slightly lower end of neutral) to avoid disrupting the skins barrier and avoid potential triggers for irritation or severe dryness

Hypersensitivity responses may manifest as urticaria, bronchospasm, or respiratory discomfort, particularly in predisposed individuals

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Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism