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Y1-R and Y2-R agonism to stimulate G i proteins and to inhibit adenylyl cyclase was monitored by detecting the ability of PYY peptides, GEP44, or GEP12 to counteract the ability of Adenosine (acting through endogenous A2B receptor and Gs proteins) to increase levels of cAMP
however, this has not been rigorously demonstrated in controlled human studies
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