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Pharmacological doses of thiamine benefit patients with the CharcotMarietooth neuropathy by changing thiamine diphosphate levels and affecting regulation of thiamine-dependent enzymes

Whatever one thinks of the regulatory process, the underlying point holds: the safety of these compounds in humans is not settled the opposite of what well tolerated vendor copy implies

doi: 10.1021/acs.jproteome.7b00035 62 Sanchez-AlvarezMZhangQFingerFWakelamMJOBakalC

Collectively, we conclude that -KG functions as an epigenetic cofactor to maintain TET-dependent DNA demethylation to facilitate YBX1 transcription, a prerequisite for AMPK translation