Mental and physical fatigue-related biochemical alterations
Symptoms suggestive of low testosterone: Reduced libido, erectile difficulty, fatigue, depressed mood, decreased initiative Reduced morning erections, slow recovery from exercise, decreased lean mass Possible gynecomastia or increased abdominal adiposity Physical and lab considerations: Obesity often lowers sex hormone-binding globulin (SHBG), which can render total testosterone normal despite functional deficiency
The remarkable part: it affects over 4,000 genes
For patients in Chicago dealing with neuropathic symptoms that have resisted gabapentin, pregabalin, or duloxetine, this mechanism offers a fundamentally different approach: rather than dulling pain signals, ReWire addresses the structural and inflammatory roots of nerve dysfunction