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Development of solidified self-microemulsifying drug delivery systems containing L-tetrahydropalmatine: design of experiment approach and bioavailability comparison

The reconstituted solution should be stored at 2C to 8C for short-term use or frozen for long-term stability

Various topical, oral, and injection-based cosmetic skin-lightening agents with different mechanisms of action are used widely across Asia, including hydroquinone, azelaic acid, kojic acid, mulberry, alpha-arbutin, beta-arbutin, glutathione, licorice root, papaya, vitamin A (e.g., retinol), vitamin B (i.e., niacinamide), and vitamin C