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Antipsychotic treatment can cause changes in the gut microbiota that induce chronic low-grade inflammation, suppress resting metabolic rates, and activate multiple signal transduction pathways, leading to metabolic dysfunction (64)

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Preclinical studies further demonstrate that combining PPR with donepezil enhances therapeutic efficacy in AD rat models by improving synaptic plasticity, reducing oxidative stress, and ameliorating histopathological outcomes (36)

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