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no large-scale controlled trials Lack of FDA approval process No sponsor has pursued formal approval Quality concerns Peptide impurities and characterization challenges in unregulated manufacturing The economic reality: Unpatentable peptides cant justify the $50100M+ investment required for Phase 3 clinical trials, which is why BPC-157 has peer-reviewed preclinical data but no completed human trials

[2] These limits specifically apply to supplemental forms, including magnesium glycinate, and are set to minimise the risk of osmotic diarrhoea, the primary adverse effect associated with excessive magnesium intake in healthy individuals

Gina: Well, one big reason is that small molecules often make for good pills

On the other hand, the ACC is thought to process sensory information within emotional and social contexts, regulating affective reactions and forming associations between sensory stimuli and their emotional values [64]