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Nissen, Chief Academic Officer of Cleveland Clinics Heart, Vascular & Thoracic Institute
They dont simply reduce appetite they alter hormonal signaling, metabolism and the brains relationship with food
Weeks 34: 2 mg once weekly (Increase only if early GI symptoms are mild and stable) Weeks 58 : 4 mg once weekly Weeks 912: 8 mg once weekly Week 13+: 12 mg once weekly (Only escalate to higher doses if indicated and previous doses were well tolerated) Balanced schedule: Standard trial-inspired ramp This schedule follows a typical balanced titration pace similar to what many clinical trials use
Here is what the key trials showed
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