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They may be a better fit for: Many users appreciate that GLP-1 medications can typically be adjusted, paused, or discontinued under medical supervision depending on personal progress and goals

Tirzepatide may aid weight loss, but Zepboundthe weight loss versionis only recommended for medically obese individuals with related health risks

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NHS England rolled out tirzepatide for weight management in cohorts after NICE TA1026 in December 2024: 3 Cohort 1 (from June 2025): adults with a body mass index (BMI) of 40 or higher and at least four of five weight-related conditions (type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease)