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In SLE, the HMGB1-TLR4 interaction promotes neutrophil NETosis, leading to the release of more HMGB1 and nuclear DNA, forming a positive feedback loop [256]

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Lastly, Brachyury expression - often considered a NC marker and required for the differentiation of mesoderm into notochord [3] - was not detected in the human adult NP, which may argue against the hypothesis that both NC and CLCs are derived from the notochord [73]

By Kayleigh Donaldson | Celebrity | January 14, 2026 Oprah Winfrey recently hosted an event for her podcast dedicated to the topic of GLP-1 medications, a.k.a