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Confirmed in isolated aortic tissue (Hsieh et al., 2020)

Maintenance and discontinuation SURMOUNT-4, continue vs placebo switch after lead-in to about 20.9% loss: stopping regained about +14% over 52 weeks while continuing lost a further -5.5%

Published studies have demonstrated effects including increased callus formation at fracture sites, enhanced osteoblast differentiation and activity, improved bone mineral density at healing sites, and acceleration of the transition from woven bone to lamellar bone

Agm antidepressant effects have been reported to depend upon both imidazoline and GABA receptors, and NMDA-NO axis inhibition (and less consistently between studies, perhaps also serotonin and adrenergic receptors), suggesting a complex ketamine-like rapid antidepressant mechanism that may involve Agm/Glu co-transmission (Uzbay, 2012