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Phase 2: Appetite Suppression Plateau (weeks 3-6 at each dose) Once GI symptoms resolve, patients enter a stable phase where appetite suppression is consistent but weight loss begins to decelerate

Multiple reaction monitoring was performed on a triple quadrupole (QqQ) mass spectrometer (ThermoFisher Scientific TSQ Quantiva) coupled with an UltiMate 3000 Dionex nano-LC system

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