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Long-term efficacy data reported so far (from GetGoal-P and GetGoal-F1) suggest that the glycemic improvement with lixisenatide is maintained, with good tolerability during long-term treatment and no increased hypoglycemia risk versus placebo [18, 22]

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To begin, we assessed overall germline sizes at the L4 stage, which were comparable in wild-type, fbf-1 fbf-2 and puf-3 puf-11 , but much smaller in quadruple mutants (Figure 4A-D)

25 , 13621373.e1365 (2017)