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Fast computations are possible with FRED, which is useful when screening libraries containing hundreds of thousands of molecules (111)

Early real-world GLP-1 data shows: - 6070% reductions in progression to diabetes - Significant decreases in cardiovascular events - Reduced need for costly downstream care such as hospitalizations and dialysis For the first time, a single class of medications has the potential to reduce spending across multiple multi-billion-dollar disease categories

Surgical or procedural solutions exist if laxity is persistent

However, 'greater on average' does not mean it works better for every person