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A growing number of companies have exited the GLP-1 market altogether, even those that relied on strict RUO labeling

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Aetna's Prior Authorization Requirements To get approved for a GLP-1 weight loss medication through Aetna, you typically need to meet all of the following criteria: BMI of 30 or higher , or a BMI of 27 or higher with at least one weight-related condition (type 2 diabetes, hypertension, dyslipidemia, or obstructive sleep apnea) Documentation of a prior weight management attempt lasting at least 6 months, which can include a structured diet program, behavioral counseling, or a previous medication trial Prescriber must be a licensed physician or advanced practice provider, and some plans require a specialist referral Aetna's clinical policy bulletin (CPB 0784) outlines these requirements in detail

Women with certain FTO gene variants (rs9939609) may be genetically predisposed to higher baseline appetite, making GLP-1 therapy particularly impactful