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The episode gets into the fact that for some peptides in particular the GLPs/Reta there are randomized controlled trials to support their specific uses, (also true for Melanotan and GH secretagouges) but many people are taking these compounds for things other than what they were studied and approved for

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A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signalling and inhibits human tumour growth in vivo

This can further lead to emotional distress, social withdrawal, and a negative impact on self-esteem and quality of life