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Concomitant use of Oxycodone and Acetaminophen Tablets with CYP3A4 inducers or discontinuation of an CYP3A4 inhibitor could decrease oxycodone hydrochloride plasma concentrations, decrease opioid efficacy or, possibly, lead to a withdrawal syndrome in a patient who had developed physical dependence to oxycodone hydrochloride

Contact your healthcare provider or pharmacist after you give yourself the injection to tell them

Hemorrhoids are associated with constipation as well (Ehrlich 2013)